We further conducted a supervised integrative feature selection with respect to BMD and constructed the inter-omics partial correlation network. Several of the identified serum metabolites including 3-phenylpropanoic acid, mainly derived from dietary polyphenols, and glycolithocholic acid, a secondary bile acid, are metabolic byproducts of the microbiota. Among the identified bacteria, Bacteroidetes and Fusobacteria were negatively associated, while Firmicutes were positively associated. Single omics association analyses identified 22 bacteria species and 17 serum metabolites for putative association with BMD. We conducted a systematic multi-omics analysis using paired metagenomic and untargeted serum metabolomic profiles from a large sample of 499 peri- and early post-menopausal women to identify the potential crosstalk between these biological factors which may be involved in the regulation of bone mineral density (BMD). While the gut microbiome has been reported to play a role in bone metabolism, the individual species and underlying functional mechanisms have not yet been characterized. 3Center of Systems Biology, Data Information and Reproductive Health, School of Basic Medical Science, Central South University, Changsha, China.2Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.1Tulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA, United States.Jonathan Greenbaum 1†, Xu Lin 2†, Kuan-Jui Su 1, Rui Gong 2, Hui Shen 1, Jie Shen 2*, Hong-Mei Xiao 3* and Hong-Wen Deng 1*
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